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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-RSV-JNJ-7184
JNJ-7184

Chemical Structure : JNJ-7184

CAS No.: 2347368-51-6

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JNJ-7184 (JNJ7184)

货号: PC-22419Not For Human Use, Lab Use Only.

JNJ-7184 is a potent, selective and non-nucleoside inhibitor of RSV-Large (L) polymerase, displays potent inhibition of both RSV-A and -B strains with EC50 of 13 and 72 nM in vitro.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JNJ-7184 is a potent, selective and non-nucleoside inhibitor of RSV-Large (L) polymerase, displays potent inhibition of both RSV-A and -B strains with EC50 of 13 and 72 nM in vitro.
JNJ-7184 targets the connector domain of RSV L polymerase.
JNJ-7184 blocks early elongation of vRNA products and partly 1st dinucleotide formation.
JNJ-7184 interacts with the connector domain (CD) located between the PRNTase and MTase domains of RSV-L.
JNJ-7184 is selective for RSV, showsweak activity against VSV, DENV-2, HIV-1 and CMV (EC50 of 3.8-79 μM).
JNJ-7184 displays little to no detectable inhibition of human DNA polymerases α, β, and γ, human mitochondrial RNA polymerase, and human RNA polymerase II (EC50 >40 uM).
JNJ-7184 inhibits RSV RNA-dependent RNA polymerase (RdRp) activity in a primer extension assay based on the purified L and P proteins (EC50=21 nM).
JNJ-7184 (1, 4 and 16 mg/kg) is highly efficacious in vivo in neonatal lambs.

物理化学性质&存储条件

分子量 510.57
分子式 C30H27FN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2S)-2-(4-(7-cyclopropyl-5-((R)-1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrazolo[1,5-a]pyrimidin-2-yl)-3-fluorophenyl)cyclopropane-1-carboxylic acid

参考文献

1. Brecht Bonneux, et al. Antiviral Res. 2024 May 19:105907.

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