JNJ-6640 | Mtb PurF inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-6640

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JNJ-6640 (JNJ6640)

货号: PC-24906Not For Human Use, Lab Use Only.

JNJ-6640 is a first-in-class potent, selective inhibitor targeting Mycobacterium tuberculosis (Mtb) PurF (IC50=1 nM), exhibits high potency against M.

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生物&药学活性

JNJ-6640 is a first-in-class potent, selective inhibitor targeting Mycobacterium tuberculosis (Mtb) PurF (IC50=1 nM), exhibits high potency against M. tuberculosis in vitro with MIC90 of 8.6 nM and MBC99.9 of 140 nM.
JNJ-6640 inhibits purine biosynthesis and affects DNA replication.
JNJ-6640 binds near the phosphoribosyl transferase (PRTase) active site in an AlphaFold model of M. tuberculosis PurF (MtPurF).
JNJ-6640 is more than 10,000-fold less active against human homologue PPAT (IC50=14 uM).
JNJ-6640 demonstrated ex vivo and in vivo efficacy.

物理化学性质&存储条件

分子量	340.36
分子式	C17H17FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-fluoro-4-(3-methyl-1H pyrazol-5-yloxy)-2-(3-(pyridin-4-yl)pyrrolidin-1-yl)pyrimidine

参考文献

1. Lamprecht DA, et al. Nature. 2025 Jun 18. doi: 10.1038/s41586-025-09177-7.

JNJ-6640 (JNJ6640)

生物&药学活性

物理化学性质&存储条件

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JNJ-6640 (JNJ6640)

生物&药学活性

物理化学性质&存储条件

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