JNJ-61393215 | OX1R inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-61393215

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JNJ-61393215 (Tebideutorexant, JNJ 61393215)

货号: PC-21917Not For Human Use, Lab Use Only.

JNJ-61393215 (Tebideutorexant) is a potent, selective orexin-1 receptor (OX1R) antagonist with pKi values of 8.17 and 8.13 for human OX1R and rat OX1R, respectively.

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生物&药学活性

JNJ-61393215 (Tebideutorexant) is a potent, selective orexin-1 receptor (OX1R) antagonist with pKi values of 8.17 and 8.13 for human OX1R and rat OX1R, respectively.
JNJ-61393215 displays >100 -fold binding affinity for human OX1R compared with human OX2R (pKi=6.12), also shows no significant affinity for a panel of other receptors, ion channels, transporters, and kinases (Eurofins).
JNJ-61393215 selectively promotes REM sleep in OX2R-knockout (KO) mice, attenuates CO2-induced fear and cardiovascular response in rats.

物理化学性质&存储条件

分子量	460.43
分子式	C23H16D2F4N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl-3,3-d2)methanone

参考文献

1. Salvadore G, et al. Transl Psychiatry. 2020 Sep 7;10(1):308.

JNJ-61393215 (Tebideutorexant, JNJ 61393215)

生物&药学活性

物理化学性质&存储条件

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JNJ-61393215 (Tebideutorexant, JNJ 61393215)

生物&药学活性

物理化学性质&存储条件

参考文献

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