JNJ-55511118 |CAS:2036081-86-2 Probechem Biochemicals

Chemical Structure : JNJ-55511118

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JNJ-55511118 (JNJ55511118)

货号: PC-35601Not For Human Use, Lab Use Only.

JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2.

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生物&药学活性

JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2.
JNJ-55511118 demonstrates excellent pharmacokinetic properties and achieves high receptor occupancy following oral administration.
JNJ-55511118 exhibits a strong reduction in certain bands on electroencephalogram, transient hyperlocomotion, no motor impairment on rotarod, and a mild impairment in learning and memory in vivo.

物理化学性质&存储条件

分子量	328.675
分子式	C14H8ClF3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one

参考文献

1. Maher MP, et al. J Pharmacol Exp Ther. 2016 May;357(2):394-414.

2. Ravula S, et al. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826.

JNJ-55511118 (JNJ55511118)

生物&药学活性

物理化学性质&存储条件

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JNJ-55511118 (JNJ55511118)

生物&药学活性

物理化学性质&存储条件

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