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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-JNJ-54175446
JNJ-54175446

Chemical Structure : JNJ-54175446

CAS No.: 1627902-21-9

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JNJ-54175446 (JNJ54175446)

货号: PC-61622Not For Human Use, Lab Use Only.

JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively.

规格 价格 库存 数量
1 mg ￥1980 In stock
5 mg ￥3980 In stock
10 mg ￥5880 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively.
JNJ-54175446 exhibits an excellent pharmacokinetic profile, good partitioning into the CNS and shows robust in vivo target engagement; orally active.

物理化学性质&存储条件

分子量 438.771
分子式 C18H13ClF4N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2-yl)-4-methyl-1,4-dihydro-5H[1,2,3]triazolo[4,5-c]pyridin-5-yl)methanone

参考文献

1. Letavic MA, et al. J Med Chem. 2017 Jun 8;60(11):4559-4572.

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