JNJ-53718678 |CAS:1383450-81-4 Probechem Biochemicals

Chemical Structure : JNJ-53718678

CAS No.: 1383450-81-4

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JNJ-53718678 (JNJ53718678;JNJ-678)

货号: PC-61493Not For Human Use, Lab Use Only.

JNJ-53718678 (JNJ53718678, JNJ-678) is a potent (Kd=7.4 nM), small-molecule inhibitor of the F-glycoprotein-mediated complex membrane fusion process of the RSV.

规格	价格	库存
10 mg	￥2280	In stock
25 mg	￥3980	In stock
50 mg	￥5580	In stock
100 mg	￥8780	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

JNJ-53718678 (JNJ53718678, JNJ-678) is a potent (Kd=7.4 nM), small-molecule inhibitor of the F-glycoprotein-mediated complex membrane fusion process of the RSV.
JNJ-53718678 displays very potent antiviral activity and low cytotoxicity.
JNJ-53718678 inhibits ESV replication in HBECs with IC50 of 1.2 nM, efficiently inhibits RSV infection in vivo.

物理化学性质&存储条件

分子量	500.921
分子式	C21H20ClF3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-indol-2-yl)methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one

参考文献

1. Roymans D, et al. Nat Commun. 2017 Aug 1;8(1):167.

2. Huntjens DR, et al. Clin Pharmacokinet. 2017 Feb 25. doi: 10.1007/s40262-017-0522-8.

3. WO2012080446 and WO2012080447.

JNJ-53718678 (JNJ53718678;JNJ-678)

生物&药学活性

物理化学性质&存储条件

参考文献

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JNJ-53718678 (JNJ53718678;JNJ-678)

生物&药学活性

物理化学性质&存储条件

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