JNJ-49095397 | p38 MAPK inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-49095397

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JNJ-49095397 (RV568, RV-568, JNJ49095397)

货号: PC-63395Not For Human Use, Lab Use Only.

JNJ-49095397 (RV-568) is a specific narrow-spectrum kinase inhibitor that inhibits a selected set of kinases involved in COPD inflammation with IC50 of 5, 40 and 52 nM for p38α, p38γ and HCK, respectively.

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生物&药学活性

JNJ-49095397 (RV-568) is a specific narrow-spectrum kinase inhibitor that inhibits a selected set of kinases involved in COPD inflammation with IC50 of 5, 40 and 52 nM for p38α, p38γ and HCK, respectively.
JNJ-49095397 (RV-568) shows potent anti-inflammatory effects in monocytes and macrophages, demonstrates synergistic interaction in poly I:C-stimulated BEAS-2B cells and in the cigarette smoke model combined with corticosteroid.

物理化学性质&存储条件

分子量	592.7
分子式	C34H36N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((4-(3-(3-tert-Butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-naphthalen-1-yloxy)methyl)yridin-2-yl)-2-methoxyacetamide

参考文献

1. Onions ST, et al. J Med Chem. 2016 Mar 10;59(5):1727-46.

2. Charron CE, et al. Eur Respir J. 2017 Oct 26;50(4). pii: 1700188.

JNJ-49095397 (RV568, RV-568, JNJ49095397)

生物&药学活性

物理化学性质&存储条件

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询单

JNJ-49095397 (RV568, RV-568, JNJ49095397)

生物&药学活性

物理化学性质&存储条件

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