JNJ-46778212 | mGlu5 PAM | Probechem Biochemicals

Chemical Structure : JNJ-46778212

CAS No.: 1363281-27-9

加入收藏

JNJ-46778212 (VU0409551, JNJ46778212)

货号: PC-60696Not For Human Use, Lab Use Only.

JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM.
JNJ-46778212 potentiates DHPG-induced long-term depression and induces calcium mobilization and ERK phosphorylation, does not potentiate mGlu5 modulation of NMDA receptor currents nor NMDA receptor-dependent long-term potentiation.
JNJ-46778212 demonstrates in vivo efficacy in multiple preclinical models of schizophrenia, coupled with good DMPK profile and acceptable therapeutic window.

物理化学性质&存储条件

分子量	352.365
分子式	C20H17FN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (35.2 mg/mL)
Chemical Name/SMILES	(4-fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone

参考文献

1. Conde-Ceide S, et al. ACS Med Chem Lett. 2015 May 20;6(6):716-20.

2. Zhou Y, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3515-9.

3. Conde-Ceide S, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434.

JNJ-46778212 (VU0409551, JNJ46778212)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JNJ-46778212 (VU0409551, JNJ46778212)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.