JNJ-42905343 | HIF-PHD inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-42905343

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JNJ-42905343 (JNJ 42905343;JNJ42905343)

货号: PC-61213Not For Human Use, Lab Use Only.

JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively.

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生物&药学活性

JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively.
JNJ-42905343 stabilizes HIF1-α in a concentration-dependent fashion in HeLa cells (EC50=19.7 uM) and stimulates the release of EPO from Hep3B cells (EC50=20.3 uM).
JNJ-42905343 increases blood haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV), corrects functional iron deficiency and inflammation-induced anaemia in rats.

物理化学性质&存储条件

分子量	394.362
分子式	C20H15FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(6-(2,6-dimethylphenoxy)-7-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid

参考文献

1. Barrett TD, et al. Br J Pharmacol. 2015 Aug;172(16):4078-88.

JNJ-42905343 (JNJ 42905343;JNJ42905343)

生物&药学活性

物理化学性质&存储条件

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JNJ-42905343 (JNJ 42905343;JNJ42905343)

生物&药学活性

物理化学性质&存储条件

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