JNJ-42314415 |CAS:1334165-90-0 Probechem Biochemicals

Chemical Structure : JNJ-42314415

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JNJ-42314415 (JNJ 42314415;JNJ42314415)

货号: PC-60796Not For Human Use, Lab Use Only.

JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A.

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生物&药学活性

JNJ-42314415 (JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A.
JNJ-42314415 inhibits rPDE10A with Ki of 64 nM, >100-fold selectivity over the other 10 PDE families.
JNJ-42314415 blocks conditioned avoidance behavior and behaviors induced by nondopaminergic stimulants (phencyclidine, scopolamine) more efficiently than D(2) receptor blockers, with less pronounced catalepsy.
JNJ-42314415 shows antipsychotic activity with an improved side-effect profile in vivo.

物理化学性质&存储条件

分子量	353.426
分子式	C19H23N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[6-(2-methoxyethyl)pyridin-3-yl]-2-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine

参考文献

1. Megens AA, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54.

JNJ-42314415 (JNJ 42314415;JNJ42314415)

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JNJ-42314415 (JNJ 42314415;JNJ42314415)

生物&药学活性

物理化学性质&存储条件

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