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首页-小分子抑制剂&激动剂-Others-Other Targets-JNJ-40929837
JNJ-40929837

Chemical Structure : JNJ-40929837

CAS No.: 1191044-42-4

JNJ-40929837 (JNJ40929837)

货号: PC-72652Not For Human Use, Lab Use Only.

JNJ-40929837 (JNJ40929837) is a potent, highly selective, oral leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 1.9 nM, demonstrates high potency (IC50=48 nM) in human whole blood ionophore-stimulated LTB4 release assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JNJ-40929837 (JNJ40929837) is a potent, highly selective, oral leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 1.9 nM, demonstrates high potency (IC50=48 nM) in human whole blood ionophore-stimulated LTB4 release assay.

    物理化学性质&存储条件

    分子量 408.52
    分子式 C22H24N4O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-((1R,3r,5S)-8-(4-(thiazolo[4,5-b]pyridin-2-yloxy)benzyl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide

    参考文献

    1. Barchuk W, et al. Pulm Pharmacol Ther. 2014 Oct;29(1):15-23.

    2. Christian Markert, et al. J Med Chem. 2021 Feb 25;64(4):1889-1903.

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