JNJ-40413269 |CAS:1184847-16-2 Probechem Biochemicals

Chemical Structure : JNJ-40413269

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JNJ-40413269 (JNJ40413269)

货号: PC-63423Not For Human Use, Lab Use Only.

JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively.

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生物&药学活性

JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively.
JNJ-40413269 exhibits a robust dose-dependent decrease in mechanical allodynia in the spinal nerve ligation model of neuropathic pain.
JNJ-40413269 strongly raises the brain levels of AEA, PEA and OEA.

物理化学性质&存储条件

分子量	393.794
分子式	C19H15ClF3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((6-(3-chloro-4-(trifluoromethyl)phenyl)pyrimidin-4-yl)amino)-1-phenylethan-1-ol

参考文献

1. Keith JM, et al. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1280-4.

JNJ-40413269 (JNJ40413269)

生物&药学活性

物理化学性质&存储条件

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JNJ-40413269 (JNJ40413269)

生物&药学活性

物理化学性质&存储条件

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