JNJ-40411813 | mGlu2 PAM | Probechem Biochemicals

Chemical Structure : JNJ-40411813

CAS No.: 1127498-03-6

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JNJ-40411813 (JNJ40411813, ADX71149)

货号: PC-61513Not For Human Use, Lab Use Only.

JNJ-40411813 (ADX71149) is a novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

JNJ-40411813 (ADX71149) is a novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM.
JNJ-40411813 displays >30-fold selectivity over mGlu1 and mGlu3-8, 10-fold over 5-HT2A.
JNJ-40411813 displays an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity; has been investigated in the clinic for schizophrenia and anxious depression disorders.

物理化学性质&存储条件

分子量	344.883
分子式	C20H25ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone

参考文献

1. Cid JM, et al. J Med Chem. 2014 Aug 14;57(15):6495-512.

2. Ahnaou A, et al. Neuropharmacology. 2016 Apr;103:290-305.

3. Lavreysen H, et al. Pharmacol Res Perspect. 2015 Mar;3(2):e00097.

4. Kent JM, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jun 3;67:66-73.

JNJ-40411813 (JNJ40411813, ADX71149)

生物&药学活性

物理化学性质&存储条件

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JNJ-40411813 (JNJ40411813, ADX71149)

生物&药学活性

物理化学性质&存储条件

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