JNJ-39393406 |CAS:953428-73-4 Probechem Biochemicals

Chemical Structure : JNJ-39393406

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JNJ-39393406 (JNJ39393406)

货号: PC-63394Not For Human Use, Lab Use Only.

JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM.

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25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM.
JNJ-39393406 does not act on α4β2, α3β4 or 5-HT3A channels, as well as α4β2, α3β4 or 5 HT3A channels, and it does not interact with a panel of 62 receptors and enzymes.
JNJ-39393406 shows bell-shaped dose-response activity in the auditory evoked potential (AEP) in DBA2 mice (0.63–5 mg/kg s.c., lower and higher doses were inactive), and model for sensory gating and the attentional set-shifting in rats.

物理化学性质&存储条件

分子量	416.389
分子式	C19H18F2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-1,2,4-Triazole-1-propanamide, 3-[(2,2-difluoro-1,3-benzodioxol-5-yl)amino]-N,N-dimethyl-5-(4-pyridinyl)-

参考文献

1. Winterer G, et al. Neuropharmacology. 2013 Jan;64:197-204.

2. Perkins KA, et al. Neuropsychopharmacology. 2018 May;43(6):1334-1342.

JNJ-39393406 (JNJ39393406)

生物&药学活性

物理化学性质&存储条件

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JNJ-39393406 (JNJ39393406)

生物&药学活性

物理化学性质&存储条件

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