JNJ-38877618 |CAS:943540-74-7 Probechem Biochemicals

Chemical Structure : JNJ-38877618

CAS No.: 943540-74-7

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JNJ-38877618 (OMO1;JNJ38877618;OMO-1)

货号: PC-63402Not For Human Use, Lab Use Only.

JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
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生物&药学活性

JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively.
JNJ-38877618 potently inhibits MET receptor phosphorylation and downstream pathway modulation in the nanomolar range and induces anti-proliferative and anti-migratory activity in models with MET gene amplification, mutant or ligand-mediated pathway activation.
JNJ-38877618 completely suppresses tumour growth SNU5 MET amplified gastric, U87-MG HGF autocrine glioblastoma and Hs746T MET exon 14 skipping mutant gastric cancer models.

物理化学性质&存储条件

分子量	374.355
分子式	C20H12F2N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(difluoro(6-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline

JNJ-38877618 (OMO1;JNJ38877618;OMO-1)

生物&药学活性

物理化学性质&存储条件

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JNJ-38877618 (OMO1;JNJ38877618;OMO-1)

生物&药学活性

物理化学性质&存储条件

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