JNJ-28312141 |CAS:885692-52-4 Probechem Biochemicals

Chemical Structure : JNJ-28312141

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JNJ-28312141 (JNJ 28312141)

货号: PC-63411Not For Human Use, Lab Use Only.

JNJ-28312141 is a potent, orally active CSF-1 receptor (CSF-1R) kinase inhibitor with IC50 of 0.69 nM.

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生物&药学活性

JNJ-28312141 is a potent, orally active CSF-1 receptor (CSF-1R) kinase inhibitor with IC50 of 0.69 nM.
JNJ-28312141 shows narrow kinase selectivity profile, also potently inhibits KIT (IC50=5 nM), AXL (12 nM), TRKA (15 nM), FLT3 (30 nM), and LCK (88 nM).
JNJ-28312141 inhibits CSF-1-induced CSF-1R phosphorylation with IC50 of 5 nM, inhibits CSF-1-dependent proliferation of mouse macrophages and CSF-1-induced expression of MCP-1 by human monocytes with IC50 of 3 nM.
JNJ-28312141 inhibits the ITD-FLT3-dependent proliferation of MV-4-11 cells with IC50 of 21 nM, inhibits FLT3 ligand-induced FLT3 phosphorylation in recombinant Baf3 cells with IC50 of 76 nM.
JNJ-28312141 demonstrates potential therapeutic activity in AML, solid tumors and bone metastases in vivo.

物理化学性质&存储条件

分子量	460.57
分子式	C26H32N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide

参考文献

1. Manthey CL, et al. Mol Cancer Ther. 2009 Nov;8(11):3151-61.

2. Illig CR, et al. J Med Chem. 2011 Nov 24;54(22):7860-83.

JNJ-28312141 (JNJ 28312141)

生物&药学活性

物理化学性质&存储条件

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JNJ-28312141 (JNJ 28312141)

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物理化学性质&存储条件

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