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Chemical Structure : JNJ-27141491

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JNJ-27141491 (JNJ 27141491;JNJ27141491)

货号: PC-60325Not For Human Use, Lab Use Only.

JNJ-27141491 is a potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM.

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生物&药学活性

JNJ-27141491 is a potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM.
JNJ-27141491 strongly suppresses MCP-1, -3, and -4-induced Ca(2+) mobilization; and leukocyte chemotaxis with IC50 of 7-97 nM, with no effect on other chemokine receptors.
JNJ-27141491 dose-dependently inhibits monocyte and neutrophil recruitment in mice.

物理化学性质&存储条件

分子量	379.38
分子式	C17H15F2N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(1S)-1-(3,4-Difluorophenyl)propyl]-2,3-dihydro-5-(5-isoxazolyl)-2-thioxo-1H-imidazole-4-carboxylic acid methyl ester

参考文献

1. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct;84(4):551-61.

2. Buntinx M, et al. J Pharmacol Exp Ther. 2008 Oct;327(1):1-9.

JNJ-27141491 (JNJ 27141491;JNJ27141491)

生物&药学活性

物理化学性质&存储条件

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JNJ-27141491 (JNJ 27141491;JNJ27141491)

生物&药学活性

物理化学性质&存储条件

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