JNJ-26993135 | LTA4H inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-26993135

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JNJ-26993135 (JNJ26993135)

货号: PC-63409Not For Human Use, Lab Use Only.

JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM.

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生物&药学活性

JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM.
JNJ-26993135 has no significant effects on LTC4, lipoxin A4, or PGE2 production.
JNJ-26993135 dose-dependently inhibits ex vivo LTB(4) production in blood (IC50=339 nM), in parallel with dose-dependent inhibition of neutrophil influx (ED50, 1-3 mg/kg) and ear edema in murine model of arachidonic acid-induced ear inflammation.
JNJ-26993135 selectively inhibited LTB(4) production, without affecting cysteinyl leukotriene production.

物理化学性质&存储条件

分子量	368.451
分子式	C20H20N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[4-(benzothiazol-2-yloxy)-benzyl]-piperidine-4-carboxylic acid

参考文献

1. Rao NL, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60.

2. Whittle BJ, et al. Br J Pharmacol. 2008 Mar;153(5):983-91.

JNJ-26993135 (JNJ26993135)

生物&药学活性

物理化学性质&存储条件

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JNJ-26993135 (JNJ26993135)

生物&药学活性

物理化学性质&存储条件

参考文献

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