JNJ-26489112 |CAS:871824-55-4 Probechem Biochemicals

Chemical Structure : JNJ-26489112

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JNJ-26489112 (JNJ26489112)

货号: PC-35481Not For Human Use, Lab Use Only.

JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures.

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生物&药学活性

JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures.
JNJ-26489112 exhibits very weak inhibition of human CA-II (IC50=35 μM).
JNJ-26489112 inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects.
JNJ-26489112 shows limited seizure spread and elevated seizure threshold in preclinical animal models.

物理化学性质&存储条件

分子量	278.707
分子式	C9H11ClN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide

参考文献

1. McComsey DF, et al. J Med Chem. 2013 Nov 27;56(22):9019-30.

JNJ-26489112 (JNJ26489112)

生物&药学活性

物理化学性质&存储条件

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JNJ-26489112 (JNJ26489112)

生物&药学活性

物理化学性质&存储条件

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