JNJ-26070109 |Cas: 844645-08-5 Probechem Biochemicals

Chemical Structure : JNJ-26070109

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JNJ-26070109 (JNJ 26070109;JNJ26070109)

货号: PC-70196Not For Human Use, Lab Use Only.

JNJ-26070109 is a novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.

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生物&药学活性

JNJ-26070109 is a novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.
JNJ-26070109 displays >1200-fold selectivity over hCCK1 receptor.
JNJ-26070109 has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively.
JNJ-26070109 inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats.

物理化学性质&存储条件

分子量	547.37
分子式	C23H17BrF2N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-Bromo-N-[1-(2,4-difluorophenyl)ethyl]-2-[[(quinoxalin-5-yl)sulfonyl]amino]benzamide

参考文献

1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36.

2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93.

JNJ-26070109 (JNJ 26070109;JNJ26070109)

生物&药学活性

物理化学性质&存储条件

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询单

JNJ-26070109 (JNJ 26070109;JNJ26070109)

生物&药学活性

物理化学性质&存储条件

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