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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Filovirus-JNJ-1953
JNJ-1953

Chemical Structure : JNJ-1953

CAS No.:

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JNJ-1953 (JNJ1953)

货号: PC-26719Not For Human Use, Lab Use Only.

JNJ-1953 is an orthoflavivirus inhibitor targeting multifunctional NS2A protein, shows nM potency against DENV-2 clinical isolates DENV-2/EDEN3295 and DENV-2/38865Y10, affects viral RNA synthesis and packaging.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JNJ-1953 is an orthoflavivirus inhibitor targeting multifunctional NS2A protein, shows nM potency against DENV-2 clinical isolates DENV-2/EDEN3295 and DENV-2/38865Y10, affects viral RNA synthesis and packaging.

物理化学性质&存储条件

分子量 567.05
分子式 C32H30ClF3N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5R,7S,8aS)-7-((R)-(4-chlorophenyl)(2-methoxy-6-(trifluoromethyl)quinolin-3-yl)methyl)-5-phenyloctahydroindolizin-7-ol

参考文献

1. Doortje Borrenberghs, et al. PLoS Pathog. 2026 May 5;22(5):e1014190.

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