JNJ-1802 (Mosnodenvir, JNJ-64281802) | DENV inhibitor

Chemical Structure : JNJ-1802

CAS No.: 2043343-94-6

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JNJ-1802 (Mosnodenvir, JNJ 1802, JNJ-64281802)

货号: PC-20177Not For Human Use, Lab Use Only.

JNJ-1802 (Mosnodenvir, JNJ-64281802) is a highly potent, pan-serotype dengue virus (DENV) inhibitor (EC50=0.04 nM-1.8 nM), blocks the NS3-NS4B interaction within the viral replication complex (EC50=1.4 nM, DENV-2).

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JNJ-1802 (Mosnodenvir, JNJ-64281802) is a highly potent, pan-serotype dengue virus (DENV) inhibitor (EC50=0.04 nM-1.8 nM), blocks the NS3-NS4B interaction within the viral replication complex (EC50=1.4 nM, DENV-2).
JNJ-1802 is highly specific for DENV and is inactive against a panel of unrelated DNA and RNA viruses.
JNJ-1802 inhibits the replication of other flaviviruses West Nile Virus (WNV), Japanese encephalitis virus (JEV) and Zika virus (ZIKV)), with mean EC50 values ranging from 0.25 µM to 1.1 µM, which is > 4,000‑fold higher than the EC50 value of JNJ-1802 for DENV‑2/16681 (IC50=0.059 nM).
JNJ-1802 shows antiviral activity and limited cellular toxicity in DENV-infected Vero, C6/36, Huh-7 and THP-1/DC-SIGN cells.
JNJ-1802 prevents de novo formation of NS3-NS4B complexes but does not disrupt established ones.
JNJ-1802 (0.2-6 mg per kg per day) exhibits a high barrier to resistance and potent in vivo efficacy in mice against infection with any of the four DENV serotypes.
JNJ-1802 is highly effective against viral infection with DENV-1 or DENV-2 in non-human primates.

物理化学性质&存储条件

分子量	582.98
分子式	C26H22ClF3N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(+)-2-(4-Chloro-2-methoxyphenyl)-2-[[3-methoxy-5-(methylsulfonyl)phenyl]amino]-1-[5-(trifluoromethoxy)-1H-indol-3-yl]ethanone

参考文献

1. Olivia Goethals, et al. Nature. 2023 Mar 15. doi: 10.1038/s41586-023-05790-6.

JNJ-1802 (Mosnodenvir, JNJ 1802, JNJ-64281802)

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JNJ-1802 (Mosnodenvir, JNJ 1802, JNJ-64281802)

生物&药学活性

物理化学性质&存储条件

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