JNJ-17203212 c TRPV1 antagonist | Probechem Biochemicals

Chemical Structure : JNJ-17203212

CAS No.: 821768-06-3

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JNJ-17203212 (JNJ17203212;JNJ 17203212)

货号: PC-42062Not For Human Use, Lab Use Only.

JNJ-17203212 is a potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

JNJ-17203212 is a potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively.
JNJ-17203212 exhibits high selectivity against a panel of receptors and transporters, and does not inhibits related TRP channels TRPV2, TRPV4, or TRPA1.
JNJ-17203212 inhibits both pH (pIC50=7.23) and capsaicin (pIC50=6.32)-induced channel activation.
JNJ-17203212 attenuates capsaicin evoked coughs, prevents core hypothermia evoked by capsaicin in vivo.

物理化学性质&存储条件

分子量	419.3243
分子式	C17H15F6N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperazinecarboxamide, 4-[3-(trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-

参考文献

1. Swanson DM, et al. J Med Chem. 2005 Mar 24;48(6):1857-72.

2. Bhattacharya A, et al. J Pharmacol Exp Ther. 2007 Nov;323(2):665-74.

3. Cefalu JS, et al. J Urol. 2009 Aug;182(2):776-85.

JNJ-17203212 (JNJ17203212;JNJ 17203212)

生物&药学活性

物理化学性质&存储条件

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JNJ-17203212 (JNJ17203212;JNJ 17203212)

生物&药学活性

物理化学性质&存储条件

参考文献

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