JNJ-1661010 | FAAH inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-1661010

CAS No.: 681136-29-8

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JNJ-1661010 (Takeda-25)

货号: PC-21982Not For Human Use, Lab Use Only.

JNJ-1661010 (Takeda-25) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 34 and 33 nM for rat FAAH and human FAAH, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
200 mg		Get quote

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生物&药学活性

JNJ-1661010 (Takeda-25) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 34 and 33 nM for rat FAAH and human FAAH, respectively.
JNJ-1661010 is >100-fold preferentially selective for FAAH-1 when compared to FAAH-2.
JNJ-1661010 dose-dependently increases arachidonoyl ethanolamide, oleoyl ethanolamide, and palmitoyl ethanolamide in the rat brain.
JNJ-1661010 attenuates tactile allodynia in the rat mild thermal injury model of acute tissue damage and in the rat spinal nerve ligation (Chung) model of neuropathic pain.
JNJ-1661010 also diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model.

物理化学性质&存储条件

分子量	365.46
分子式	C19H19N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

参考文献

1. Keith JM, et al. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43.

JNJ-1661010 (Takeda-25)

生物&药学活性

物理化学性质&存储条件

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JNJ-1661010 (Takeda-25)

生物&药学活性

物理化学性质&存储条件

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