JNJ-16259685 | mGluR1 antagonist | Probechem Biochemicals

Chemical Structure : JNJ-16259685

CAS No.: 409345-29-5

加入收藏

JNJ-16259685 (JNJ16259685)

货号: PC-42138Not For Human Use, Lab Use Only.

JNJ-16259685 (JNJ16259685) is a highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2380	In stock
50 mg	￥3980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JNJ-16259685 (JNJ16259685) is a highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM.
JNJ-16259685 shows no agonist, antagonist or PAM activity toward rat mGlu2/3/4/6 receptors (IC50>10 uM) and does not bind to AMPA, NMDA receptor and other neurotransmitter receptors.
JNJ-16259685 inhibits glutamate-induced Ca2+ mobilization for rat and human mGluR1 with IC50 of 3.24 and 1.21 nM, inhibits glutamate-mediated inositol phosphate production with IC50 of 1.73 nM.
JNJ-16259685 attenuates drug context-induced reinstatement of cocaine seeking in rats.

物理化学性质&存储条件

分子量	325.4015
分子式	C20H23NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-

参考文献

1. Lavreysen H, et al. Neuropharmacology. 2004 Dec;47(7):961-72.

2. Mabire D, et al. J Med Chem. 2005 Mar 24;48(6):2134-53.

3. Xie X, et al. Psychopharmacology (Berl). 2010 Jan;208(1):1-11.

JNJ-16259685 (JNJ16259685)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JNJ-16259685 (JNJ16259685)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.