JNJ-10229570 | MC1R/MC5R antagonist | Probechem Biochemicals

Chemical Structure : JNJ-10229570

CAS No.: 524923-88-4

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JNJ-10229570 (JNJ10229570, JNJ 10229570)

货号: PC-35970Not For Human Use, Lab Use Only.

JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively.
JNJ-10229570 dose dependently inhibited the production of sebaceous lipids in cultured primary human sebocytes.
Topical treatment with JNJ-10229570 of human skins transplanted onto SCID mice resulted in a marked decrease in sebum-specific lipid production, sebaceous gland's size and the expression of the sebaceous differentiation marker epithelial-membrane antigen (EMA).

物理化学性质&存储条件

分子量	389.47
分子式	C22H19N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)-

参考文献

1. Eisinger M, et al. J Dermatol Sci. 2011 Jul;63(1):23-32. doi: 10.1016/j.jdermsci.2011.04.001.

JNJ-10229570 (JNJ10229570, JNJ 10229570)

生物&药学活性

物理化学性质&存储条件

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JNJ-10229570 (JNJ10229570, JNJ 10229570)

生物&药学活性

物理化学性质&存储条件

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