JNJ-10198409 |CAS:627518-40-5 Probechem Biochemicals

Chemical Structure : JNJ-10198409

加入收藏

JNJ-10198409 (JNJ10198409)

货号: PC-62328Not For Human Use, Lab Use Only.

JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM.

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM; displays >10-fold selectivity over PDGFRα (IC50=45 nM), and 5-fold over c-ABL (IC50=22 nM), >500-fold over a panel of kinases; also has modest activity against have modest activity against c-Src/Lck/Fyn (IC50=185/100/378 nM); shows potent antiproliferative activity for human tumor cell lines (IC50=33 nM); regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency.

物理化学性质&存储条件

分子量	325.343
分子式	C18H16FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine

参考文献

1. Ho CY, et al. J Med Chem. 2005 Dec 29;48(26):8163-73.

2. D'Andrea MR, et al. Mol Cancer Ther. 2005 Aug;4(8):1198-204.

3. Ball SG, et al. Stem Cells. 2012 Mar;30(3):548-60.

JNJ-10198409 (JNJ10198409)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JNJ-10198409 (JNJ10198409)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.