JND003 | ERRα agonist | Probechem Biochemicals

Chemical Structure : JND003

加入收藏

JND003 (JND 003)

货号: PC-49158Not For Human Use, Lab Use Only.

JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter.
JND003 (5.0 μM) potently and selectively agonizes the transcriptional function of ERRα in AAB-Luc cells, displays no obvious effect on ERRβ and ERRγ, as well as other nuclear hormone receptors, such as ERα, ERβ, ERγ and PPARγ.
JND003 (10.0 μM) reduces lipid accumulation and enhances fatty acid oxidization in HepG2-IR cells.
JND003(30mg/kg, oral) exhibits high grade of distribution in liver and abdominal adipose tissues， improves insulin sensitivity, alleviates liver steatosis and serum lipid disorders in HFD-fed C57 mice.

物理化学性质&存储条件

分子量	266.300
分子式	C16H14N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methoxy-3-methyl-2-phenyl-4(3H)-Quinazolinone

参考文献

1. Liufeng Mao, et al. ACS Bio Med Chem Au. 2022 Jun 15;2(3):282-296.

JND003 (JND 003)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JND003 (JND 003)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.