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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monoamine Transporter-JN-170
JN-170

Chemical Structure : JN-170

CAS No.: 3032920-98-9

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JN-170 (JN170)

货号: PC-25027Not For Human Use, Lab Use Only.

JN-170 is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 97 nM against mouse SLC6A19 in the isoleucine transport assay, > 10-fold less potent against human SLC6A19 (IC50=1.25 μM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JN-170 is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 97 nM against mouse SLC6A19 in the isoleucine transport assay, > 10-fold less potent against human SLC6A19 (IC50=1.25 μM).
JN-170 (50 -250 mg/kg, oral) caused a dose-dependent increase in urinary amino acid excretion in WT C57Bl/6J mice.
JN-170 significantly drove reductions in plasma Phe in an exposure-related manner.

物理化学性质&存储条件

分子量 434.42
分子式 C20H21F3N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(2-(1-aminocyclopropyl)ethyl)-3-(3-(4-cyanophenyl)-1,2,4-oxadiazol-5-yl)-3-(trifluoromethyl)pyrrolidine-1-carboxamide

参考文献

1. Wobst HJ, et al. JCI Insight. 2024 Nov 8;9(21):e182876.

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