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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-CMV-JMX0493
JMX0493

Chemical Structure : JMX0493

CAS No.: 1096316-34-5

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JMX0493 (JMX-0493)

货号: PC-47051Not For Human Use, Lab Use Only.

JMX0493 is a potent inhibitor of human adenoviruse (HAdV) infection with IC50 of 0.78 uM (HAdV-5), targets HAdV entry pathway and prevents viral particle disassembly and subsequent release from the endosome.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JMX0493 is a potent inhibitor of human adenoviruse (HAdV) infection with IC50 of 0.78 uM (HAdV-5), targets HAdV entry pathway and prevents viral particle disassembly and subsequent release from the endosome.
JMX0493 displayed significant activity in the qPCR assay, inhibiting or delaying HAdV-5 DNA replication by 50% at a concentration of 7.8 uM.
JMX0493 stabilizes HAdV capsid, also shows broad antiviral activity against human cytomegalovirus (HCMV) in a DNA replication assay.

物理化学性质&存储条件

分子量 267.753
分子式 C14H18ClNO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-chloro-N-(cyclohexylmethyl)-2-hydroxybenzamide

参考文献

1. Jimin Xu, et al. Int J Mol Sci. 2021 Feb 5;22(4):1617.

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