JMX0286 | SARS-CoV-2 3CLPro inhibitor | Probechem Biochemicals

Chemical Structure : JMX0286

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JMX0286 (JMX 0286)

货号: PC-49140Not For Human Use, Lab Use Only.

JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells.

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生物&药学活性

JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells.
JMX0286 shows little to no inhibitor activity against cathepsin B (CatB) and L (CatL) enzymes with IC50 of >100 uM.
JMX0286 effectively inhibits the cleavage of the TriPro substrate protein in a dose dependent manner.
JMX0286 directly and specifically to an allosteric pocket of the SARS-CoV-2 3CL protease with KD value of 9.8 uM in SPR assays.

物理化学性质&存储条件

分子量	463.696
分子式	C17H17Cl3N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-aminoethoxy)-5-chloro-N-(2-((2-chloro-4-nitrophenyl)amino)-2-oxoethyl)benzamide hydrochloride

参考文献

1. Samrat SK, et al. Antiviral Res. 2022 Jul 11;205:105381.

JMX0286 (JMX 0286)

生物&药学活性

物理化学性质&存储条件

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JMX0286 (JMX 0286)

生物&药学活性

物理化学性质&存储条件

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