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首页-小分子抑制剂&激动剂-GPCR-Neurotensin Receptor-JMV449
JMV449

Chemical Structure : JMV449

CAS No.: 139026-66-7

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JMV449 (JMV-449)

货号: PC-20496Not For Human Use, Lab Use Only.

JMV449 (JMV-449) is a potent, metabolically stable neurotensin receptor agonist peptide with IC50 of 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain.

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5 mg ￥3980 In stock
10 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JMV449 (JMV-449) is a potent, metabolically stable neurotensin receptor agonist peptide with IC50 of 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain.
JMV449 produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

物理化学性质&存储条件

分子量 746.96
分子式 C38H66N8O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((S)-2,6-diaminohexyl)-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

参考文献

1. D Lugrin, et al. Eur J Pharmacol. 1991 Nov 26;205(2):191-8.

2. I Dubuc, et al. Eur J Pharmacol. 1992 Aug 25;219(2):327-9.

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