JMV-7061 | Metallo-β-lactamase inhibitor | Probechem Biochemicals

Chemical Structure : JMV-7061

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JMV-7061 (JMV7061)

货号: PC-49547Not For Human Use, Lab Use Only.

JMV7061 (JMV-7061) is a novel potent, selective bacterial metallo-β-lactamase (MBL) inhibitor, shows submicromolar activities against VIM-type enzymes and strong NDM-1 inhibition (Ki=10-30 nM).

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生物&药学活性

JMV7061 (JMV-7061) is a novel potent, selective bacterial metallo-β-lactamase (MBL) inhibitor, shows submicromolar activities against VIM-type enzymes and strong NDM-1 inhibition (Ki=10-30 nM).
JMV7061 inhibited both VIM-2 and NDM-1 at least partially by stripping the catalytic zinc ions.
JMV7061 also displayed a very potent synergistic activity with meropenem (16- to 1000-fold MIC reduction) against VIM-type- and NDM-1-producing ultraresistant clinical isolates, including Enterobacterales and Pseudomonas aeruginosa.
JMV7061 exhibited no or moderate toxicity toward HeLa cells, favorable absorption, distribution, metabolism, excretion (ADME) properties.
JMV7061 displayed no or modest inhibition of several mammalian metalloenzymes.

物理化学性质&存储条件

分子量	452.54
分子式	C21H24N8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(bis((1H-imidazol-4-yl)methyl)amino)-5-(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)pentanoic acid

参考文献

1. Alice Legru, et al. J Med Chem. 2022 Dec 22;65(24):16392-16419.

JMV-7061 (JMV7061)

生物&药学活性

物理化学性质&存储条件

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JMV-7061 (JMV7061)

生物&药学活性

物理化学性质&存储条件

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