JMS-175-2

Chemical Structure : JMS-175-2

加入收藏

货号: PC-23075Not For Human Use, Lab Use Only.

JMS-175-2 is a specific, small molecule inhibitor Zn2+-dependent JAMM/MPN deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC) with IC50 of 3.8 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JMS-175-2 is a specific, small molecule inhibitor Zn2+-dependent JAMM/MPN deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC) with IC50 of 3.8 uM.
JMS-175-2 does not inhibit AMSH* (a STAM2 AMSH fusion), the nuclear ARISC complex, UPS2, and BRCC36 Abraxas2 complex.
JMS-175-2 inhibits BRISC-mediated cleavage of polyubiquitin chains.
JMS-175-2 acts as molecular glue, stabilises two BRISC octamers to form a BRISC dimer with 16 subunits.
JMS-175-2 (2.5 uM) reduces interferon-stimulated gene (ISG) expression in cells MCF10A Cas9 cells expressing BRCC45 wild-type (WT), and in healthy and SSc PBMCs.
BRCC36 is a JAMM (JAB1, MOV34, and MPR1, Pad1 N-terminal (MPN)) metalloenzyme DUB family and selectively cleaves lysine 63-linked ubiquitin (K63-Ub) chains.
BRCC36 is present in two distinct macromolecular assemblies: a cytoplasmic BRCC36 isopeptidase complex (BRISC), and the nuclear Abraxas1 isopeptidase complex (ARISC).
The BRISC complex regulates Type I interferon signalling by deubiquitylating and stabilising Type I interferon (IFNAR1) receptors, whilst the ARISC complex interacts with the tumour suppressor protein BRCA1 and localises to double-stranded DNA breaks to facilitate DNA damage repair.

物理化学性质&存储条件

分子量	555.24
分子式	C23H19Cl4N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,6-dichlorobenzamido)-1-(2,6-dichlorobenzoyl)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide

参考文献

1. Chandler F, et al. bioRxiv. 2024 Sep 7:2024.09.07.611787.

JMS-175-2

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JMS-175-2

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.