JMS-17-2 |CAS:1380392-05-1 Probechem Biochemicals

Chemical Structure : JMS-17-2

CAS No.: 1380392-05-1

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JMS-17-2

货号: PC-35323Not For Human Use, Lab Use Only.

JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM).

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM).
JMS-17-2 effectively blocks FKN-induced ERK phosphorylation, also significantly reduces the migration of breast cancer cells in vitro.
JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells, shows long-term anti-tumor effects in vivo.

物理化学性质&存储条件

分子量	419.953
分子式	C25H26ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one

参考文献

1. Shen F, et al. Mol Cancer Res. 2016 Jun;14(6):518-27.

2. Stout MC, et al. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2264-2269.

3. Naya A, et al. J Med Chem. 2001 Apr 26;44(9):1429-35.

JMS-17-2

生物&药学活性

物理化学性质&存储条件

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JMS-17-2

生物&药学活性

物理化学性质&存储条件

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