JMKX1899 | KRAS G12C inhibitor | Probechem Biochemicals

Chemical Structure : JMKX1899

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JMKX1899 (JMKX-1899)

货号: PC-27036Not For Human Use, Lab Use Only.

JMKX1899 is a potent and selective, covalent, BBB-penetrating KRAS G12C inhibitor.

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100 mg		Get quote

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生物&药学活性

JMKX1899 is a potent and selective, covalent, BBB-penetrating KRAS G12C inhibitor.
JMKX1899 effectively and selectively inhibits cell growth in nearly all KRAS G12C-mutated cell lines but has no effect on non-KRAS G12C-mutated cell lines.
JMKX1899 (1 nM) significantly reduced the p-ERK/ ERK and p-AKT/ AKT ratio in the H358 cell line.
JMKX1899 inhibits tumor growth in vivo in KRAS G12C-mutant subcutaneous xenograft tumor models.
JMKX1899 can penetrate the CNS and achieve tumor regression in BM models.
JMKX1899 demonstrates profound antitumor activity in BM models compared to AMG510.

物理化学性质&存储条件

分子量	688.20
分子式	C36H39ClFN7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,4aR)-3-acryloyl-11-chloro-6-(2-(dimethylamino)ethyl)-10-(2-fluoro-6-hydroxyphenyl)-8-(2-isopropyl-4-methylpyridin-3-yl)-2-methyl-2,3,4,4a,6,8-hexahydro-1H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-5,7-dione

参考文献

1. Danming He, et al. J Natl Cancer Cent. 2025 Dec 5;6(3):286-296.

JMKX1899 (JMKX-1899)

生物&药学活性

物理化学性质&存储条件

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JMKX1899 (JMKX-1899)

生物&药学活性

物理化学性质&存储条件

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