JM6 | KMO inhibitor | Probechem Biochemicals

Chemical Structure : JM6

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JM6 (KMO inhibitor JM6)

货号: PC-62659Not For Human Use, Lab Use Only.

JM6 (KMO inhibitor JM6) is an orally bioavailable small-molecule prodrug of Ro 61-8048, which is an inhibitor of kynurenine 3-monooxygenase (KMO).

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生物&药学活性

JM6 (KMO inhibitor JM6) is an orally bioavailable small-molecule prodrug of Ro 61-8048, which is an inhibitor of kynurenine 3-monooxygenase (KMO).
JM6 inhibits KMO in the blood, increases kynurenic acid levels and reduces extracellular glutamate in the brain.
JM6 prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer's disease.

物理化学性质&存储条件

分子量	518.61
分子式	C23H26N4O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-dimethoxy-N-(4-(3-nitrophenyl)-5-(piperidin-1-ylmethyl)thiazol-2-yl)benzenesulfonamide

参考文献

1. Zwilling D, et al. Cell. 2011 Jun 10;145(6):863-74.

2. Rojewska E, et al. Neuropharmacology. 2016 Mar;102:80-91.

3. Beconi MG, et al. Drug Metab Dispos. 2012 Dec;40(12):2297-306.

JM6 (KMO inhibitor JM6)

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物理化学性质&存储条件

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JM6 (KMO inhibitor JM6)

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