JL5 |CAS: 2244238-50-2 Probechem Biochemicals

Chemical Structure : JL5

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JL5 (BMP receptor inhibitor JL5)

货号: PC-63322Not For Human Use, Lab Use Only.

JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively.

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生物&药学活性

JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively.
JL5 shows much weaker acitivity against BMPR2, ALK5/TGFβR1 and TGFβR2 with IC50 of 8,510, 440 and 40 nM.
JL5 shows a greater volume of distribution and suppresses the expression of Id1 and pTak1 in tumor xenografts, induces tumor cell death and tumor regression in xenograft mouse models without immune cells and humanized with adoptively transferred human immune cells.

物理化学性质&存储条件

分子量	449.558
分子式	C28H27N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)propyl)morpholine

参考文献

1. Newman JH, et al. Oncogene. 2018 Apr 6. doi: 10.1038/s41388-018-0156-9.

JL5 (BMP receptor inhibitor JL5)

生物&药学活性

物理化学性质&存储条件

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JL5 (BMP receptor inhibitor JL5)

生物&药学活性

物理化学性质&存储条件

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