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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-JL-03
JL-03

Chemical Structure : JL-03

CAS No.:

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JL-03 (JL03)

货号: PC-28705Not For Human Use, Lab Use Only.

JL-03 is a potent, covalent, chemically stable eIF4E inhibitor with IC50 of 128 nM in FP assays, covalent modifies Lys162 of eIF4E, suppresses translation of the oncogenic driver cyclin D, decreases cell viability in HOXA9-high MV4-11 AML, displays localized synergy with revumenib in MV4-11 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JL-03 is a potent, covalent, chemically stable eIF4E inhibitor with IC50 of 128 nM in FP assays, covalent modifies Lys162 of eIF4E, suppresses translation of the oncogenic driver cyclin D, decreases cell viability in HOXA9-high MV4-11 AML, displays localized synergy with revumenib in MV4-11 cells.

物理化学性质&存储条件

分子量 600.11
分子式 C27H26ClN5O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-(5-chloro-2-(2-(2,6-dimethyl-4-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-3(4H)-yl)ethoxy)phenyl)-N-(vinylsulfonyl)thieno[3,2-b]pyridine-3-carboxamide

参考文献

1. Pal P, et al. ACS Chem Biol. 2026 Nov 3. doi: 10.1021/acschembio.6c00714.

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