JKA3 inhibitor 31 |CAS:1637749-82-6 Probechem Biochemicals

Chemical Structure : JKA3 inhibitor 31

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JKA3 inhibitor 31 (JAK3 covalent inhibitor)

货号: PC-62261Not For Human Use, Lab Use Only.

JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases.

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生物&药学活性

JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases.
JKA3 inhibitor 31 also inhibits BLK, ERB-B4 and ITK with IC50 of 22 nM, 44 nM and 221 nM, respectively.

物理化学性质&存储条件

分子量	288.31
分子式	C17H12N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(1H-indazol-4-yl)phenyl)-2-cyanoacrylamide

参考文献

1. London N, et al. Nat Chem Biol. 2014 Dec;10(12):1066-72.

2. Clark JD, et al. J Med Chem. 2014 Jun 26;57(12):5023-38.

JKA3 inhibitor 31 (JAK3 covalent inhibitor)

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物理化学性质&存储条件

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JKA3 inhibitor 31 (JAK3 covalent inhibitor)

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物理化学性质&存储条件

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