JK184 |CAS:315703-52-7 Probechem Biochemicals

Chemical Structure : JK184

CAS No.: 315703-52-7

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JK184 (JK-184;JK 184)

货号: PC-43482Not For Human Use, Lab Use Only.

JK184 is an antagonist of the hedgehog (Hh) signaling pathway with IC50 of 30 nM, inhibits glioma (Gli)-dependent transcriptional activity.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2280	In stock
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生物&药学活性

JK184 is an antagonist of the hedgehog (Hh) signaling pathway with IC50 of 30 nM, inhibits glioma (Gli)-dependent transcriptional activity.
JK184 inhibits GLI1 mRNA expression and decreases the number of colonies formed in TN-IBC (SUM149) and TNBC (MDA-MB-231 and SUM159) cell lines.
JK184 significantly down-regulates GLI1 targets that regulate cell cycle (cyclin D and E) and apoptosis (Bcl2).
JK184 is a potent inhibitor of microtubule assembly and that microtubule-depolymerizing agents can either negatively or positively regulate the Gli family of transcription factors, dependending on the mechanism by which the pathway is activated.

物理化学性质&存储条件

分子量
分子式	C19H18N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiazolamine, N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-

参考文献

1. Cupido T, et al. Angew Chem Int Ed Engl. 2009;48(13):2321-4.

2. Colavito SA, et al. Breast Cancer Res. 2014 Sep 25;16(5):444.

3. Oladapo HO, et al. Cancer Lett. 2017 Dec 28;411:136-149.

4. Lee J, et al. Chembiochem. 2007 Nov 5;8(16):1916-9.

JK184 (JK-184;JK 184)

生物&药学活性

物理化学性质&存储条件

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JK184 (JK-184;JK 184)

生物&药学活性

物理化学性质&存储条件

参考文献

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