JK-273 | α4 integrin inhibitor | Probechem Biochemicals

Chemical Structure : JK-273

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JK-273 (JK273)

货号: PC-61417Not For Human Use, Lab Use Only.

JK-273 is a small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin.

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生物&药学活性

JK-273 is a small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin.
JK-273 inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity).
JK-273 causes cell cycle arrest at S phase and induces apoptosis.

物理化学性质&存储条件

分子量	335.795
分子式	C18H14ClN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-aminophenyl)-N-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

参考文献

1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80.

2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360.

JK-273 (JK273)

生物&药学活性

物理化学性质&存储条件

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JK-273 (JK273)

生物&药学活性

物理化学性质&存储条件

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