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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoacylglycerol Lipase (MAGL)-JJKK-048
JJKK-048

Chemical Structure : JJKK-048

CAS No.: 1515855-97-6

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JJKK-048 (JJKK 048, JJKK048)

货号: PC-60701Not For Human Use, Lab Use Only.

JJKK-048 (JJKK048) is a potent, highly selective monoacylglycerol lipase (MAGL) with IC50 of <0.4 nM against human and rodent MAGL.

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JJKK-048 (JJKK048) is a potent, highly selective monoacylglycerol lipase (MAGL) with IC50 of <0.4 nM against human and rodent MAGL。
JJKK-048 exhibits extremely high potency in inhibiting MAGL in the brain and peripheral tissues and maintains good selectivity over other serine hydrolases。
JJKK-048 remarkably increases mouse brain 2-AG levels without affecting AEA levels, induces antinociception and dose-dependent hypomotility and hypothermia but no catalepsy in vivo.

物理化学性质&存储条件

分子量 434.44
分子式 C23H22N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

{4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone

参考文献

1. Aaltonen N, et al. Chem Biol. 2013 Mar 21;20(3):379-90.

2. Aaltonen N, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):62-72.

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