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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-JJ-450
JJ-450

Chemical Structure : JJ-450

CAS No.: 2772026-11-4

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JJ-450 (JJ450)

货号: PC-49173Not For Human Use, Lab Use Only.

JJ-450 is a novel analogue of IMTPPE and direct and specific inhibitor of androgen receptor (AR) transcriptional activity, blocks AR recruitment to androgen-responsive elements and suppresses AR target gene expression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JJ-450 is a novel analogue of IMTPPE and direct and specific inhibitor of androgen receptor (AR) transcriptional activity, blocks AR recruitment to androgen-responsive elements and suppresses AR target gene expression.
    JJ-450 also inhibits ARv7 transcriptional activity and its target gene expression.

    物理化学性质&存储条件

    分子量 372.868
    分子式 C21H22ClFN2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-(5-chloro-2-methylphenyl)piperazin-1-yl)(2-(4-fluorophenyl)cyclopropyl)methanone

    参考文献

    1. Yang Z, et al. Mol Cancer Ther. 2020 Jan;19(1):75-88.

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