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首页-小分子抑制剂&激动剂-Others-Other Targets-JI051
JI051

Chemical Structure : JI051

CAS No.: 2234281-75-3

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JI051 (JI 051;JI-051)

货号: PC-35091Not For Human Use, Lab Use Only.

JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression.

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5 mg ￥3280 In stock
25 mg ￥6880 In stock
100 mg ￥17800 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JI051 (JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression.
JI051 inhibits HEK293 cell proliferation with EC50 of 0.3 uM, interacts with prohibitin 2 (PHB2), stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest.
JI051 dose-dependently reduces cell growth of the human pancreatic cancer cell line MIA PaCa-2.

物理化学性质&存储条件

分子量 364.445
分子式 C22H24N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-(2-ethoxyphenethyl)-3-(7-methoxy-1H-indol-3-yl)acrylamide

参考文献

1. Perron A, et al. J Biol Chem. 2018 Mar 9. pii: jbc.RA118.002316.

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