欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-JHU395
JHU395

Chemical Structure : JHU395

CAS No.: 2079938-92-2

加入收藏

JHU395 (JHU-395)

货号: PC-38668Not For Human Use, Lab Use Only.

JHU395 is orally-bioavailable glutamine antagonist prodrug, shows antitumor activity in malignant peripheral nerve sheath tumor (MPNST, sNF96.2 cell growth IC50=4.6 uM).

规格 价格 库存 数量
5 mg ￥1480 In stock
10 mg ￥2280 In stock
25 mg ￥3980 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JHU395 is orally-bioavailable glutamine antagonist prodrug, shows antitumor activity in malignant peripheral nerve sheath tumor (MPNST, sNF96.2 cell growth IC50=4.6 uM).
JHU395 exhibits increased metabolic stability in swine and human plasma, favorable conversion in brain homogenate, and substantially improved CNS delivery in vivo in swine, compare with 6-diazo-5-oxo-L-norleucine (DON).
JHU395 attenuates glutamate synthesis in HIV-infected microglia/macrophages, offering therapeutic potential for HIV-associated neurocognitive disorders (HAND).
JHU395 also decreased growth and increased apoptosis in multiple human high-MYC medulloblastoma cell lines at lower concentrations than DON.

物理化学性质&存储条件

分子量 447.488
分子式 C22H29N3O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-Diazo-N-[[(2,2-dimethyl-1-oxopropoxy)phenylmethoxy]carbonyl]-5-oxo-L-norleucine 1-methylethyl ester

参考文献

1. Nedelcovych MT, et al. J Med Chem. 2017;60:7186–98.

2. Lemberg KM, et al. Mol Cancer Ther. 2020 Feb;19(2):397-408.

3. Khoa Pham, et al. J Neuropathol Exp Neurol. 2021 Mar 22;80(4):336-344.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: