JHU37160 | DREADD agonist | Probechem Biochemicals

Chemical Structure : JHU37160

CAS No.: 2369979-68-8

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JHU37160 (JHU 37160)

货号: PC-73159Not For Human Use, Lab Use Only.

JHU37160 is a high affinity, highly potent, BBB penetrant activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro.

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25 mg	￥680	In stock
50 mg	￥980	In stock
100 mg	￥1580	In stock
250 mg		Get quote

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生物&药学活性

JHU37160 is a high affinity, highly potent, BBB penetrant activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro.
JHU37152 selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites.
JHU37152 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons.
Designer receptors exclusively activated by designer drugs (DREADD) technology is a powerful chemogenetic approach used for neuromodulation in uninstrumented research animals.

物理化学性质&存储条件

分子量	358.85
分子式	C19H20ClFN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine

参考文献

1. Jordi Bonaventura, et al. Nat Commun. 2019 Oct 11;10(1):4627.

JHU37160 (JHU 37160)

生物&药学活性

物理化学性质&存储条件

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JHU37160 (JHU 37160)

生物&药学活性

物理化学性质&存储条件

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