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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glutaminase-JHU-083
JHU-083

Chemical Structure : JHU-083

CAS No.: 1998725-11-3

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JHU-083 (JHU083;JHU 083)

货号: PC-35603Not For Human Use, Lab Use Only.

JHU-083 is an orally available prodrug of the glutaminase inhibitor 6-diazo-5-oxo-L-norleucine (DON), blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress..

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JHU-083 is an orally available prodrug of the glutaminase inhibitor 6-diazo-5-oxo-L-norleucine (DON), blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

物理化学性质&存储条件

分子量 312.37
分子式 C14H24N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (S)-2-((S)-2-amino-4-methylpentanamido)-6-diazo-5-oxohexanoate

参考文献

1. Zhu X, et al. Neuropsychopharmacology. 2018 Aug 13. doi: 10.1038/s41386-018-0177-7.

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