JH-VIII-49 |CAS:2209084-73-9 Probechem Biochemicals

Chemical Structure : JH-VIII-49

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JH-VIII-49

货号: PC-63464Not For Human Use, Lab Use Only.

JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM).

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生物&药学活性

JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM).
JH-VIII-49 displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition.
JH-VIII-49 induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM).

物理化学性质&存储条件

分子量	428.664
分子式	C30H40N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,8S,10R,13S,14S,17S)-17-(isoquinolin-7-yl)-N,N,10,13-tetramethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-amine

参考文献

1. John M. Hatcher, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00011

JH-VIII-49

生物&药学活性

物理化学性质&存储条件

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JH-VIII-49

生物&药学活性

物理化学性质&存储条件

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