JH-ENT-01

Chemical Structure : JH-ENT-01

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货号: PC-23917Not For Human Use, Lab Use Only.

JH-ENT-01 is a potent, specific inhibitor of the equilibrative nucleoside transporter subtype 1 (ENT1) with Ki of 92.7 nM, shows good selectivity for hENT1 over hENT2.

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生物&药学活性

JH-ENT-01 is a potent, specific inhibitor of the equilibrative nucleoside transporter subtype 1 (ENT1) with Ki of 92.7 nM, shows good selectivity for hENT1 over hENT2.
JH-ENT-01 preferentially inhibits wild type hENT1 over G154S by about two-fold.
JH-ENT-01 reduces formalin-induced acute inflammatory pain, exhibits analgesic efficacy in animal models of diabetic neuropathy and nerve injury as well as of inflammatory pain.

物理化学性质&存储条件

分子量	725.79
分子式	C37H47N3O12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(3-((3,4-dimethoxy-5-((4-nitrobenzyl)oxy)benzoyl)oxy)propyl)-1,4-diazepan-1-yl)propyl 3,4,5-trimethoxybenzoate

参考文献

1. Wright NJ, et al. Nat Commun. 2024 Dec 30;15(1):10738.

JH-ENT-01

生物&药学活性

物理化学性质&存储条件

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JH-ENT-01

生物&药学活性

物理化学性质&存储条件

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